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R., Wouters, H

Acetyl-L-Carnitine (ALC) Acetyl-L-Carnitine vs L-Carnitine Acetyl-L-carnitine (ALCAR) demonstrates superior blood-brain barrier penetration and enhanced neuroprotective effects compared to L-carnitine (LCAR), making it the preferred choice for neurological applications, while both compounds show similar efficacy for peripheral and metabolic indications

2021: A systematic review of 11 RCTs in 203 adults found some improvements in VOmax and peak power, but no studies showed benefit for moderate-intensity exercise [3][61]

Sci Pharm 85(1):4 [DOI] [PMC free article] [PubMed] [Google Scholar] Kandemir MF, Kkler S, alayan C, Gr C, Batl AA, Gulcin I (2017b) Therapeutic effects of silymarin and naringin on methotrexate-induced nephrotoxicity in rats: biochemical evaluation of anti-inflammatory, anti-apoptotic and anti-autophagic properties