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9 Discussion With the increase in lifespan and NCDs, disorders of cellular metabolism that include DM and neurodegenerative disorders are increasing in prevalence throughout the world

The proposed mechanism for cell damage following ischemia is oxidative stress and inflammation

Am J Clin Nutr 2000 Aug;72(2 Suppl):618S-23S Volek JS, Kraemer WJ, Rubin MR, Gomez AL, Ratamess NA, Gaynor P

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Levels of reactive oxygen species (ROS) produced during the stress impair mitochondrial DNA and result in dysfunctional electron transport chains and reduced ATP synthesis

PPAR activation by l-Carnitine reduces hypertension-associated renal fibrosis 12