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This work was partly supported by the World Premier International Research Center Initiative, MEXT, Japan

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DAloisio V, Schofield A, Kendall DA, Hutcheon GA, Coxon CR

It represses autophagy in degenerative and metabolic disorders by destabilizing or activating inhibitory transcripts while promoting autophagy in cancers by stabilizing key ATG mRNAs or enhancing mitophagy pathways

NU: Supervision, Validation, Writing review & editing

For example, in older adults with spinal stenosis, this may be an alternative less risky treatment compared to other options