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In this test, a bolus of monosaccharide (mannitol or L-rhamnose) and disaccharide (lactulose) is consumed orally

doi: 10.1124/jpet.113.203489

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Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism

Bilbao A, Spanagel R

Much of the research framing treats it as an orally administered compound, and in practitioner circles it circulates in oral/sublingual forms (capsules, or the reconstituted solution taken sublingually)