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The peptide activates the VEGFR2-Akt-eNOS signaling cascade, leading to increased vascular endothelial growth factor (VEGF) expression and subsequent vessel development

The molecular docking dynamics revealed the great affinity of AFB1 to the SOD1, SOD2, GPx, GR, GCLC, and GSH synthase binding sites, with binding energy values of 5.34, 4.85, 5.57, 5.71, 7.26, and 6.69 kcal/mol, respectively (Figures 4AF)

doi:10.1128/jb.177.1.247-251.1995

even the ones that are available provide moderate relief

Acknowledgements This work was supported by the National Institute of Environmental Health Sciences at the National Institutes of Health (documents ES035019 and ES025750 to JRC)

Taken together, these findings suggest that PQQ could serve as a potential therapeutic agent for neurodegenerative diseases associated with microglia activation, potentially slowing their progression (Peng et al., 2020