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Many studies have demonstrated the existence of a biased agonism for OR at different signaling events including desensitization, phosphorylation, endocytosis, trafficking, and in vivo effects (see below) (Raehal et al., 2011

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[DOI] [PubMed] [Google Scholar] 180.Amaral E.P., Conceio E.L., Costa D.L., Rocha M.S., Marinho J.M., Cordeiro-Santos M., DImprio-Lima M.R., Barbosa T., Sher A., Andrade B.B
