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Progressive depletion of cellular glutathione is also used as a mechanism by many viruses to control their replication cycle during infection

doi: 10.3390/nu17152537 25 ChenQ.FanY.ZhangB.YanC.ZhangQ.KeY.et al

M., Hendey B., Monahan A

The electrons stored in NADH (and FADH2) produced as a result of the TCA cycle activity are transferred through a series of protein complexes of the ETC to oxygen (Figure 1, below)

The case of NAC encapsulates the core challenges of MIRI therapy: while its mechanism of enhancing endogenous defenses is conceptually superior to direct scavenging (as argued in Section 2.3), its clinical potential is ultimately nullified by the formidable practical hurdles of delivery and timing required to counteract the rapid and localized oxidative burst (Section 2.1)