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adequately powered, dose-standardized comparisons versus corticosteroids are needed before routine substitution ( 5.5 OSF and oral precancer trials There have been at least 5 controlled trials in OSF and a few in leukoplakia

doi: 10.1097/JS9.0000000000001466 189

Numerous studies have shown that long-term exposure to PM10, SO2, NO2, CO, cadmium and ammonia can induce and exacerbate inflammatory responses in the nasal cavity, leading to olfactory dysfunction (166,167)

This systematic review ultimately included 19 studies, consisting of 14 RCTs, 2 usability studies, and 3 experimental studies (Figure 1, Table 1, Supplementary Table 1) ( Figure 1 Table 1 Studies included in the analysis

Molecular structures of siRNA are subjected to chemical modifications, such as the addition of 2-O-methyl or 2-fluoro replacements (106), in order to enhance their stability and reduce the occurrence of off-target effects, while simultaneously enhancing transport efficiency and limiting adverse effects

These method-specific alterations in protein quality may be due to the activity of proteolytic enzymes (Luo et al., 2014)