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It is an essential nutrient, meaning that it cannot be synthesized by the body and must be obtained through diet or supplements

doi: 10.1242/jcs.01188

Pickart estimated the toxic dose for humans at approximately 22,500 mg, which sits roughly 3,750 times higher than a typical weekly therapeutic dose
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It also modulates pineal gland function and circadian biologyrestoring nighttime melatonin release and normalizing disrupted sleepwake rhythms in older humans and animals

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