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As the interaction between Atox1 and ATP7A and ATP7B is dependent on copper binding, the GSH/GSSG ratio bidirectionally modulates the flow of copper through the secretory pathway by regulating the redox state of Atox1

Essential role of p53 in silica-induced apoptosis

Koopdonk-Kool JM, de Vijlder JJ, Veenboer GJ, Ris-Stalpers C, Kok JH, Vulsma T, et al

[DOI] [PubMed] [Google Scholar] 55.Liu Y., Yan H., Yu B., He J., Mao X., Yu J., Zheng P., Huang Z., Luo Y., Luo J., et al

ROS plays a crucial regulatory role in macrophage polarization, with its production during macrophage differentiation primarily controlled by Nox isoenzymes

The relatively high level of GSH and GSH/GSSG in transgenic plants was controlled by the increased GR activity and the decreased DHAR activity, which might rebuild the new cellular redox balance in OE plants