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Theyre a popular choice for a reason, but they arent the only optionand for many people, they arent the most effective one

As pointed out [60], it has to be the counteraction of the reduced capillary perfusion pressure, increased cerebral blood volume, venous flow obstruction, increased intracranial pressure and blood-brain barrier disruption, resulting in a decreased cerebral blood flow [60]

But since B12 is important for your overall health, you should prob up your intake anyway

Whats the Verdict on Vitamin B12 for Pain Relief

PMID: 41380824 J Physiol Sex-specific metabolic responses to glucagon receptor agonism and modulation of the FGF21-glucagon axis in female mice