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Headache and brain fog are some of the minor side-effects that Ive read

Your body burns stored fat for energy more efficiently while storing less new fat from your diet

Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)

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This synergistic effect arises because a lowcalorie diet reduces fat intake, while it promotes lipolysis and energy expenditure, together achieving more efficient fat reduction and metabolic improvement

For example, concurrent use of chloramphenicol (an antibiotic) may attenuate the hematologic response to vitamin B therapy