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Food and Drug Administration for therapeutic or medical use
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After treatment, brain tissues were harvested and evaluated for oxidative stress biomarkers (8-OHdG, MDA, GPx, GSH, GST, SOD), pro-inflammatory cytokines (MPO, NF-B, TNF-), ion transport enzymes (Na/K ATPase, Ca ATPase), neurotransmitter levels (dopamine, serotonin, AChE), and the apoptotic marker caspase-3
The recommended effective dosage for its antioxidant effect is 125 mg to 300 mg daily for 2 months
Therefore, targeting ferroptosis emerges as a promising strategy for amyotrophic lateral sclerosis treatment
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