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Regarding hepatic pathological setting, mitochondrial glutathione plays a critical role in the survival of hepatocytes during hypoxia through the regulation of mitochondrial generation of oxidative stress [71]

As discussed in the previous section, there are two enzymes of creatine synthesis, glycine amidinotransferase (encoded by the GATM gene ) and guanidinoacetate N -methyltransferase (encoded by the GAMT gene), and one major creatine transporter encoded by the SLC6A8 gene

This can also lead to other opportunistic diseases including diabetes and digestive disorders

Compared with normal tissues, the difference in GSTP1 expression is associated with multiple diseases (Table III)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [184].Zhou B, Liu J, Kang R, et al
