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In the 2020 s, MSCs emerged as a central focus in the field of regenerative medicine, with significant advancements in the clinical implementation of MSC-based therapies

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For example, myocardial dysfunction has been linked to mitochondrial dysfunction caused by copper deficiency-induced expression of molecules related to mitochondria (100)

Park S, Kim D, Jang I, Oh HB, Choe J (2014) Structural and biochemical study of Bacillus subtilis HmoB in complex with heme

Immunomodulation and paracrine signalling MSC secretome and especially EVs have shown protective effects in OA joints by promoting proliferative and anti-apoptotic effects 81

doi: 10.1186/1745-6215-15-115
