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Description
Regional brain metabolism during seizures in humans
Despite short serum half-life, daily dosing produces robust, sustained tissue-repair effects in rodent models
The activity of the mitochondrial enzymes aconitase, -ketoglutarate dehydrogenase (-KGDH), succinate dehydrogenase (SDH), complex I (NADH dehydrogenase), and complex V was significantly reduced after exposure to L-Glu at 80 mM [61]
CC, convalescent control
Genet 41 , 234239 (2009)
Although functional evidence is currently lacking, similar mechanisms may also occur in the gut where 5HT3Rs are abundantly expressed, for example, on inhibitory motor neurons in the ENS, 305 which comprise the majority of GABAergic neurons
