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(PubMed) Yu JJ, Pei LB, Zhang Y, Wen ZY, Yang JL

Additionally, protocols involving healthy volunteers should incorporate precautions in the event of the following: Serious Adverse Reaction in One Subject Defined measures and actions that need to be taken in the case of a serious adverse reaction in a single subject

Some causes of orange urine are serious conditions that require medical diagnosis and treatment.

USA 91 , 1062510629 (1994)

Previous research has suggested that hepatic GJ proteins might facilitate the spread of free radicals, thereby exacerbating the severity of drug-induced liver damage (Patel et al