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24 Plethora of preclinical and clinical findings has highlighted the significance of Delta4Notch signalling as one of the pathways mediating the tumor refractoriness to anti-VEGF therapy

2006;31(10):E3026

Epitalon: No significant adverse effects in decades of preclinical study

At the 0.25mg starting dose, a 5mg vial theoretically lasts 20 weeks

This dosage range derives from extrapolation of effective animal doses using standard interspecies scaling factors
