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the Key Project of the National Natural Science Foundation of China (U20A20354)

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Zheleznyak A, Tang R, Duncan K, Manion B, Liang K, Xu B, et al

69 Crucially, these effects happen at doses which are inside the normal physiological range for circulating endogenous ghrelin

GHRH is produced by the hypothalamus and triggers the pituitary gland to produce hGH (or growth hormone), which triggers the production of IGF-1 in the liver

Phosphorylation modification enhances DSIP activity The 7-serine residue of delta-sleep can be phosphorylated to generate P-DSIP, which has a biological activity 5-300 times higher than DSIP