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Transcriptome profiling of advanced stage lipedema patients confirmed mitochondrial and metabolic disfunctions and highlighted Sirtuin signaling alteration Together with DNA methylation profile, transcriptome reprogramming has emerged to have a significant on impact cellular behaviour and to contribute to disease development or progression

Both complexes generated DNA strand breaks given byat least partiallythe oxidation of pyrimidine bases, which caused the arrest of the cell cycle in the G2/M phase

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Tumor volume was calculated using the formula: Volume = (Length Width)/2

Additionally, flavonoids suppress SREBP-1c-driven lipogenesis and enhance PPAR--mediated -oxidation, thereby alleviating hepatic lipid accumulation (Liu et al., 2021b)