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Description
RNAi-mediated gene silencing in non-human primates
ERS occurs when the folding capacity of the ER is overwhelmed, leading to an accumulation of misfolded or unfolded proteins

Puglisi I, Lo Cicero L, Lo Piero AR

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Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in beta-thalassemia/HbE patients

Left: Many cancer cells generate large amounts of ROS and RNS but also have elevated antioxidant defenses, largely through upregulation of the Trx and GSH systems
