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Conversely, overexpression of GCLC or GPX4 in CD8 T cells enhances their antitumor capacity, confirming that equipping (CAR) T cells with enhanced redox resistance is beneficial for improving cancer immunotherapy
Chauhan A, Chauhan V, Brown T (2010) Autism: oxidative stress, inflammation, and immune abnormalities

In addition, several residues (C670T675) that link the N-terminus of this long -CT helix to the N-terminus of the unliganded -CT interact with the FnIII-1 domain, and serve as an anchor to couple the two -CTs (Fig

The treatment carries certain risks, such as allergic reactions, kidney or thyroid damage, infections, ochronosis, and toxicity

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Schoonen L, et al
