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Autism spectrum disorders are increasingly being recognised as a major public health issue

A 2008 study published in the Journal of Medicinal Chemistry demonstrated metabolic effects in rodent models at 50mg/kg, which led early researchers to extrapolate human-equivalent doses between 50100mg daily

[DOI] [PMC free article] [PubMed] [Google Scholar] 131.Prescott SL, Jenner DA, Beilin LJ, Margetts BM, Vandongen R

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The effect of injury severity on behavior: A phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice