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The study measured 24-hour melatonin rhythms before and after a course of epithalamin administration in older adults whose age-related pineal-gland melatonin rhythms had become attenuated

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Random effect models were used to estimate odds ratios (ORs) and mean differences with 95% confidence interval (CI)
Its neuroregulatory effects on the hypothalamus and GABAergic systems further contribute to improved overall sleep quality (2)

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