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ACTM-838 (Actym Therapeutics) is designed to co-deliver IL-15 with a STING agonist for the dual activation of innate and adaptive immunity (81)

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This transporter is densely expressed in astrocytic processes abutting glutamatergic and GABAergic neurons (Boulland et al., + concentrations (Brer et al., + in astrocytes during re-accumulation of excess extracellular K + from the extracellular space after neuronal excitation (Xu et al., 2013) might therefore increase glutamine release

doi: 10.1007/s10787-023-01416-5

Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study