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4.8 Fragile X syndrome FXS is the most prevalent inherited intellectual disability, emerging early in life with a range of impairments including deficits in communication skills, cognitive abilities, physical features, as well as epilepsy, anxiety, and heightened sensitivity to stimuli (215)

For example, enhancing oxidative phosphorylation in microglia might promote a more quiescent, neuroprotective state, while targeted inhibition of glycolysis could reduce harmful inflammation (Barros et al., 2009

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By bridging traditional practices with modern scientific understanding, this review underlines the growing relevance of shiitake not only as a functional food and therapeutic resource but also as a component of sustainable food systems and bio-based waste management strategies