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3.2 Target trimethylamine N-oxide generation pathway 3.2.1 Trimethylamine inhibitor There are four main enzymes involved in the production of TMA: choline-TMA lyase (CutC/D), carnitine monooxygenase (CntA/B), betaine reductase, and TMAO reductase (Koeth et al., 2014

Choose L-carnitine if you focus on fat oxidation, endurance performance, or metabolic health, but carefully consider cardiovascular risk factors and monitor TMAO levels for long-term use

Valproate toxicity and ornithine carbamoyltransferase deficiency

Red meats (i.e., beef, pork, & mutton) contain much more L-carnitine than dairy products, eggs, poultry or seafood and far more than plant foods

To execute this analysis, we utilised the CAUSALMED procedure, which allowed us to calculate the total, direct and indirect mediation effects of TMAO

Always take it with water and food