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According to our findings, a maternal high-sucrose (44%) diet increased MC4R levels in the synaptosomal fraction of the NAc and dSTR in female Wistar offspring at PND63 [92]
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This activation is at least in part mediated by the RhoGEF proteins which stimulate activation of Rho GTPase that consequently binds and activates PLC independently on RA2 binding [11, 14]
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