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[DOI] [PubMed] [Google Scholar] 30.Lu H., Tang S., Xue C., Liu Y., Wang J., Zhang W., Luo W., Chen J

Inhibitors of FAK that target the ATP-binding pocket of the kinase domain have been largely unsuccessful 10,11 , displaying micromolar anti-proliferative effects and no apoptotic effects in cancer cells despite reported nanomolar biochemical potencies for the FAK enzyme 12,13