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F344 rats treated with pipermethystine (10 mg/kg) for 2 weeks resulted in significant increase in hepatic glutathione, cytosolic superoxide dismutase (Cu/ZnSOD), tumor necrosis factor alpha mRNA expression, and cytochrome P450 (CYP) 2E1 and 1A2, suggesting that pipermethystine caused adaptation to oxidative stress and possible drug-drug interactions (10)

The cis double bonds, which are necessary for the process of decorating, may be converted into cyclopropane by MmaA2 and PcaA [36, 59], or converted into a trans double bond by UmaA1 [60], or hydrated into hydroxylated mycolates by MmaA4 [53, 57, 61, 62]

ATP-induced inflammation drives tissue-resident Th17 cells in metabolically unhealthy obesity

SIRT1/3 and AMPK/PGC-1 to promote mitochondrial biogenesis and quality control

Frataxin is an iron chaperone that drives the assembly of the Fe-S cluster in mitochondria, while it has recently been identified as a key regulator of ferroptosis by modulating mitochondrial iron homeostasis [140]

R.HaasR.JuncosJ