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36 EftekhariA.AhmadianE.AzarmiY.ParvizpurA.HamishehkarH.EghbalM

Translocated to the nucleus, Nrf2 binds to Antioxidant Response Element (ARE) sequences in the promoter regions of numerous antioxidant enzymes, including glutathione S-transferase, NAD(P)H:quinone oxidoreductase 1, and heme oxygenase-1, effectively amplifying endogenous antioxidant capacity (103, 104)

Regulatory approvalsEstablishing safe guidelines for inhalation, oral intake, or dialysate use

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When Glu release increases or reuptake is inhibited, continuous stimulation of NMDAR by Glu leads to massive calcium influx, resulting in excitotoxicity (Beas-Zarate et al., 2008)

NCBI PMC - l-Carnitine Supplementation in Recovery after Exercise, 2018