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B: However, in the endothelial cells with high level of phosphor AKT, following the block of VEGF stimulation, the AKT pathway remains active inducing transcription of FGF, an angiogenic factor, which on one side promotes endothelium proliferation and on the other further phosphorylates AKT producing a positive loop

Samini F., Samarghandian S., Borji A., Mohammadi G., and bakaian M., Curcumin Pretreatment Attenuates Brain Lesion Size and Improves Neurological Function Following Traumatic Brain Injury in the Rat, Pharmacology, Biochemistry and Behavior 110 (2013): 238244

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