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A Role for Endothelial Cell Lipoxygenase in the Oxidative Modification of Low Density Lipoprotein

Metabolism of tyrosine and tryptophannew genes for old pathways

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Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens

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17,20 This mechanism has been implicated in neuropsychiatric disorders such as Alzheimers disease, Parkinsons disease, epilepsy, and anxiety-like behaviors, 16,21,22 suggesting a broader role for astrocytic GABA dysregulation in brain dysfunction
