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Description
CKD results in an altered equilibrium between activation of IGF-1 and SOCS, toward a markedly increased SOCS synthesis, which is most likely due to CKD-associated chronic inflammation resulting in a state of GH-insensitivity [156, 157]

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doi: 10.1007/s00204-019-02555-x 5 AlexanderB

Conversely, when healing is no longer a realistic goal, as in palliative wound care, the focus shifts toward pain reduction, exudate management, odor management, and/or other quality-of-life benefits to wound care

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Bartl R
