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There are no known toxic effects when administered at appropriate levels
Regular monitoring ensures B12 levels remain within the therapeutic range whilst minimising potential adverse effects
The mechanism by which CD38 mediated PD-1/PD-L1 blockade resistance likely includes perturbation of adenosine receptor signaling in tumor microenvironment leading to immune modulation (87)
For a 100kg person, that translates to approximately 22.5kg (49.5 pounds) over 18 months
Vitamin B12 is like the backstage crew of a theatre production
