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The presence of four closely clustered metalliganding Cys and/or His residues as in canonical ZF proteins, are often simply assumed to bind Zn II often with little empirical evidence

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While C and S drive weight loss by reducing energy intake (EI) 11,14,15 , it is less clear whether they also affect energy expenditure (EE)

This is supported by a concomitant decrease in levels of the lipid peroxidation biomarker 8-isporostane