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The IDEA trial (Messier 2013 JAMA) earlier showed that 10 percent weight loss produces significant knee pain improvement
The 1 mg/day arm produced 2.6 kg weight loss over 12 weeks versus 0.8 kg placebo
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If your levels were very low, this early phase can feel especially noticeable
[DOI] [PubMed] [Google Scholar] 9.Thatte MR, Babhulkar S, Hiremath A
