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However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements

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For example, if the standard deviation of a task duration is small, the confidence interval will be narrowindicating a more predictable outcome

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loss of meanings, understandings, and other concept-based knowledge)