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Vecchiet L, Di Lisa F, et al

Lipids play a central role in metazoan physiology, as they affect cellular and organismal functions in three principal, non-exclusive ways: (i) in signaling cascades, both directly as signaling molecules (e.g., diacylglycerol, fatty acids, phosphatidylinositols, sterols, ceramides, and sphingolipids), and indirectly by reversibly and irreversibly tethering signaling proteins to cellular membranes (e.g., via prenylation or palmitoylation)