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Proteins and lipids are also nitrated and S-nitrosylated by ONOO -

These include decreased sperm count, motility and morphology in males, as well as adverse pregnancy outcomes in females, such as maternal thyroid dysfunction and congenital hypothyroidism

Kazan and Manners, 2011), and pathogens (Qi et al., 2018)

It is commonly investigated in preclinical research models relating to metabolic signalling pathways, cellular energy regulation, and enzymatic activity associated with nicotinamide N-methyltransferase (NNMT) interaction studies

Acknowledgments We thank Elze Leite for the administrative support

Thereafter, several variants of this model have been reported using mice of different strains, different ages or micro-coils of smaller or larger diameters (375)