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A randomized trial demonstrated that weekly oral vitamin D supplementation during neoadjuvant therapy significantly improved pathologic complete response rates in breast cancer patients, particularly those with hormone receptornegative tumors and high Ki67 expression
Lauras B, Drevon B, Rolland MO, Teyssier G, Bovier-Lapierre M, Freycon F
However, the high hydrophobicity and poor bioavailability limit the further application of Cur
In addition, -KG can be utilized via malic enzyme to generate NADPH, a process that supports glutathione regeneration (Cluntun et al., 2017)
One study successfully increased lubricin (lubricating protein) concentration in superficial zone chondrocytes
