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USA 116 , 2424224251 (2019)
2007;130(Pt 12):311123
Three major protein subfamilies have been reported to exhibit glutathione transferase activity: Cytoplasmic, mitochondrial and microsomal GSTs (4,5)
Additionally, metformin modulates immune function and inhibits excessive inflammation, such as by reducing levels of pro-inflammatory cytokines like IL-6 and TNF-, thereby alleviating cytokine storm-induced insulin resistance (141, 142)
2-deoxy-D-glucose, a glucose analogue that competitively binds to the glycolytic rate-limiting enzyme, glucose hexokinase, blocks NETosis by inhibiting glycolysis (138)
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