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doi: 10.1074/jbc.C200673200

After clearance of CMV replication, a reduction of CD38 hi -expressing clusters occurred while the CPT1a + cluster no

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In conclusion, the study robustly demonstrated that FOXO4-DRI selectively eliminates senescent Leydig cells, reduces detrimental SASP factor secretion, improves the testicular microenvironment, and ultimately enhances sperm quality and spermatogenesis in aged mice, positioning it as a promising therapeutic candidate for age-related male infertility [2]
