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Crocodilian oil may also activate peroxisome proliferator-activated receptor gamma (PPAR- ), contributing to anti-inflammatory effects, improved cellular survival, and reduced neutrophil migrationactions believed to be PPAR- dependent (9)

This powerful antioxidant plays a crucial role in supporting and enhancing various aspects of immune function

Moreover, SCFAs, particularly butyrate, produced during probiotic fermentation, are known to activate sirtuin 1 (SIRT1), a critical transcriptional regulator that may enhance the expression of antioxidant genes such as GSH, GST, GCL and contributing towards the systemic oxidative balance 91,92,93

Elevated levels of proinflammatory cytokines (Khaibullin et al., 2017) and increased levels of chemokines responsible for recruiting peripheral immune cells and activating the adaptive immune response (Kalinowska-yszczarz et al., 2011), have been found in MS patients

10.1136/openhrt-2015-000300 182

Both glycine and glutamate are also byproducts of central carbon metabolism (glycolysis or TCA cycle, respectively) (Figure 2.10 and 2.11)
