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The success of compounds such as APR-246, CP-31398, and MIRA-1 as well as gene therapies and immunotherapies in preclinical and early clinical settings for blood cancers, along with ongoing clinical trials (Table 6), is a testament to their promise in treating hematologic malignancies

pubescens Huang essential oil inhibited nitric oxide production in dose-dependent manner in LPS-induced RAW 264.7 cells

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Mechanistically, sulforaphane, by virtue of forming dithiocarbamate through a reaction with thiol groups, can directly interact with DNA binding and the transactivation of NF-B [325]

Abrams et al

Therefore, to explore the link between TNF- and the ROS-dependent mode of cell death, the experimental groups were examined by flow cytometry, which revealed that TPA caused a marked increase in ROS, whereas 200 ng/ml TNF- significantly reversed the increase in ROS (Fig