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Brainheart interactions in the neurobiology of consciousness

Research has identified potential interactions with NMDA receptor modulation and MAPK signalling pathways, with data suggesting structural homology to glucocorticoid-induced leucine zipper (GILZ) a protein involved in anti-inflammatory and immune-regulatory signalling via the ERK pathway

(1) Neurodevelopmental Homeostasis: In the healthy state, mitochondrial oxidative phosphorylation (Complexes IV) supports efficient ATP generation, redox stability, and formate flux from the mitochondrial folate cycle (via SHMT2, MTHFD2)