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Because the mitochondrial inner membrane is exposed to an oxidant abundant environment and consists of high levels of cardiolipin, a LA-rich membrane lipid when dietary LA is high, 687 it is not surprising that linoleate oxidation products including HODEs, DiHOMEs, TriHOMEs, oxo-OMEs, oxo-EpOMEs, HpODEs and Hp-oxo-OMEs are constitutive members of the mitochondrial lipidome

Subsequent plasma sample non-targeted metabolomics studies found that larger changes in lysophosphatidyl and lysophosphatidylcholine metabolites in intermittent CR were associated with greater reductions in memory T cell subsets and greater increases in naive T cell subsets (161)