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Ablation of hepatocyte Smad1, Smad5 , and Smad8 causes severe tissue iron loading and liver fibrosis in mice

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"I expected stress was bad for the body," said Prof Hsu

These systems may represent new horizons for compounds that have not been clinically tested thus far or that have previously failed in clinical settings as potential ATs

An improved understanding of the molecular mechanisms involved in mitochondrial pathology will aid in developing more targeted diagnostic and therapeutic strategies

Dysregulation of this axis underpins a wide array of pathologies, from myocardial infarction and heart failure to stroke, hypertension, and neurodegenerative disorders, driven by mechanisms such as sympathetic overactivation, inflammatory cascades, and hormonal imbalances