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The symptoms of ME/CFS include: chronic exhaustion (more than tired difficulty staying upright, feeling ill) post-exertional malaise, PEM (inability to recover from activity) pain and flu-like symptoms cognitive dysfunction (brain fog+) a general reduction in the overall quality of life, such as being unable to keep a job or regularly attend school This is more than just feeling tired

1C), suggesting that cystine starvation induced the amino acid response but not the ER stress signaling within the ISR

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