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Rates of deficiency increase with age
F.DiNicolantonioJ
Highlights of the first century of human tumour virology
Nat Genet 33 : 177182
this chronic low-grade inflammation activates the hypothalamic-pituitary-adrenal axis, elevating cortisol levels, which promotes visceral fat storage and impairs insulin sensitivity
In this state, the GPX4 is active in cells, and lipid peroxides are reduced, therefore leading to ferroptosis resistance
